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4 weeks 1 x 10 mL bottle 3 vials use 9 mL 6 weeks 2 x 10 mL bottles 6 vials use 18 mL 8 weeks 3 x 10 mL bottles 8 vials use 24 mL 12 weeks 4 x 10 mL bottles 13 vials use 39 mL Round up for priming losses, dropped syringes, and damaged swabs

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Even with Fc engineering to reduce FcR binding, the potent payload and efficient delivery system may have led to unacceptable on-target/off-tumor toxicity in tissues with basal HER2 expression

Kalinkova M, Kadiyska T, Handjieva-Darlenska T