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Both the thioredoxin (Trx) and GSH-dependent glutaredoxin (Grx) antioxidant systems have been found to reduce methionine sulfoxide reductases in vitro and/or in vivo (see Figure 2 ) (28)
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A dose that produces an effect in a mouse does not scale linearly to a human by body weight, and the research doses in this protocol are practitioner-derived conventions, not figures validated against human outcomes
As an important group of antioxidative enzymes, the normal levels of GPxs help to control the level of reactive species
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