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The suppression of IEG induction, specifically in the dentate gyrus, was associated with significant changes to behavioral immobility responses 24 h later, suggesting that SAMe may enhance behavioral responses after stress by suppressing the induction of IEG

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Overt liver diseasethe earliest symptoms of which are yellowing of the skin and darkening of the urineis rare

This procedure is not recommended for pregnant or breastfeeding individuals, those with severe allergies, or those with an active infection or skin condition in the treatment area