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Nevertheless, available evidence indicates that prolonged exposure to supraphysiological doses of AAS is associated with a substantial risk of adverse psychological outcomes, including the development of dependence and persistent emotional and interpersonal difficulties (62)
In mice, the bulk of the metabolic improvement seen upon FGF21 treatment derives from centrally mediated weight loss, whereas FGF21 analogs elicit limited weight loss in humans
The diversity of mechanisms is a strength, not a complication
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