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2) Cellular Growth in Human Myotubes In human cell models 4 , IGF-1 directly drives hypertrophy markers (greater nuclei per myotube, higher fusion index, elevated contractile protein content), reinforcing its role in the cellular foundation of strength and size gains
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The use of the Ca 2+ -sensitive receptor (CaSR) inhibitor NPS-2143 can block the carnitine-induced increase in the cytoplasmic Ca 2+ concentration, indicating that carnitine-induced Ca 2+ mobilization is mediated by the activation of CaSR [119]
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