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Animal toxicology studies have shown that semaglutide can cause thyroid C-cell tumors in rodents in a dose- and duration-dependent manner

Effects of GLP-1 and GIP receptor agonists include: Stimulating insulin secretion in response to food (glucose-dependent) Reducing inappropriate glucagon release, lowering hepatic glucose output (GLP-1 enhances the sensitivity of alpha cells to glucose , resulting in more glucose-appropriate glucagon secretion) When blood glucose is high, insulin secretion is stimulated and glucagon secretion is inhibited

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Structural studies of NAD(+)-dependent methanol dehydrogenase 1 from Bacillus [PMID: 41123439] Laboratory literature summary: Structural studies of NAD(+)-dependent methanol dehydrogenase 1 from Bacillus methanolicus MGA3