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However, the suitability of current in vitro models, including those based on ARPE-19 cells, for accurately recapitulating RPE physiology in the context of diabetes warrants further optimization

The researchers identified the PI3K/AKT signaling pathway as a key mechanism mediating Dihexa's cognitive benefits, expanding the mechanistic understanding beyond the original HGF/c-Met focus

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Each subgroup included three to five animals