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Cancer Cell 24(4):450465

70 BCKDK inhibitors are also effective in attenuating insulin resistance in mouse models of obesity, and the development of a new generation of more powerful BCKDK inhibitors is important for diseases that require inhibition of BCAA catabolism

They get sequestered in the body that nobody can get to

Using our previously described DMS library that covers all possible point mutations within 10 of the IMiD-binding site of CRBN 49 , we found that rac -dHTC1 and SR-1114 are sensitive to similar CRBN mutations (Extended Data Fig