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The research is clear, and the answer may disappoint people looking for a definitive winner
But it creates three immediate nutritional risks: Inadequate protein intake muscle loss alongside fat loss, lowering metabolism long-term Dehydration reduced thirst cues lead to worsening constipation, fatigue, and headaches Nutrient deficiencies smaller portions mean less iron, B12, calcium, and fibre unless meals are planned The STEP-1 clinical trial showed that participants on semaglutide who also followed a structured, reduced-calorie eating pattern lost an average of 14.9% of their body weight over 68 weeks
9 At system level, oral GLP-1s also align with scalable healthcare delivery models
The Aging Process: Natural production typically begins to decline after age 20, often dropping by about 10% per decade
