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What we DO know, however, is that only 20% (or even less) of the people with symptomatic B12 deficiency have anaemia or altered size of the red blood cells

The REDEFINE 1 Phase 3 trial (Garvey et al., 2025) provides the closest analog for combination tolerability

Furthermore, the trajectory of the weight loss curves suggested that at 48 weeks the plateau of weight was not yet reached and all the participants in the 8 and 12 mg had a weight reduction of 5% or more, which is currently the minimum threshold for efficacy [64]