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Critically, comparable weight loss was not observed in RAMP1/RAMP3 knockout mice, confirming that the effect depends on AMYR and AMYR signaling rather than CTR activation alone
Natural active compounds including polysaccharides, polyphenols, and flavonoids can modulate gut microbiota structure and influence metabolic pathways such as tryptophan-indole and tyrosine-p-cresol
However, the exact connection between the peptide and this pathway is still not fully understood
Gut 60(10): 13941402
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