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Thiol redox status regulate MPT and enhanced ROS generation can target critical cysteine residues in cyclophilin D, implying that mGSH depletion would favor MPT via redox pathways targeting MPT components
Single-nucleotide variant (SNV) and small insertion/deletion (INDEL) identification was based on Mutect2 of the Genome Analysis Toolkit, the detected variants were annotated using ANNOVAR, and pathogenicity was assessed using the ClinVar_20210501 database [15, 16]
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