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These mechanisms do not act independently but form an integrated regulatory network, with SIRT1 positioned centrally within the metabolismimmuneorgan axis. In processes including energy sensing, transcriptional control, redox balance, and cell fate determination, SIRT1 consistently occupies a central or upstream role in signal coordination, capable of orchestrating multiple pathways
Taken together, chemically specified microbial metabolites, rather than generic MAMPs, can act as antigens that license unconventional T cells
The determinants of functional and regulatory changes in GGT and ChaC1/ChaC2 across different malignancies or settings remain elusive
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