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GSH is exclusively degraded at the extracellular level by cells expressing -glutamyltranspeptidase (GGT), such as those of the hepatobiliary tree and of other organs like the heart, kidney, lungs, pancreas, and seminal vesicles
Mechanically, artesunate upregulated the expression of autophagy-associated proteins and inhibited the expression of FTH1 and NCOA4, indicating that ferritinophagy-mediated ferroptosis in HSCs is crucial in the antifibrotic therapy of artesunate (Kong et al., 2019)
Despite its growing popularity, the clinical efficacy and safety of BPC-157 remain unproven, raising significant ethical and legal concerns
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