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The expected effect in PCOS is modest around 13 kg over 612 months, slightly more in women with higher starting weight and a strong insulin-resistance picture
Some patients need a slower ramp if side effects appear
Bloating is common during the first few weeks, especially at each dose increase
Weve seen that while both are highly effective in their own right, and both are once-weekly injectable drugs that are approved by the FDA, they operate with distinct mechanismssemaglutide as a GLP-1 receptor agonist and tirzepatide as a dual GLP-1/GIP receptor agonist
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