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Screening of cord blood in neonates for G6PD deficiency is a popular method especially in low-middle income countries with high prevalence
Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau
This encourages clients to stay involved
In fact, we previously reported that systemic MOTS-c treatment reversed diet-induced obesity and diet- and age-dependent insulin resistance in mice 15
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