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Moreover, in response to stress, p66Shc (which functions in the intracellular pathways that convert oxidative signals into apoptosis) translocates to mitochondria to directly stimulate hydrogen peroxide generation by transferring electrons to cytochrome c
Recently, a novel AFB 1 -aldehyde reductase (AFB 1 -AR) purified from ethoxyquin (EQ)-treated rat liver has been shown to metabolize the dialdehyde form of AFB 1 -dihydrodiol to an AFB 1 -dialcohol and its relative importance in AFB 1 detoxification may be considerable [35]
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