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Gastrointestinal diseases that damage enterocytes (the cells lining the intestines) may result in decreased DAO activity because this is where DAO is produced
Trial of antisense oligonucleotide tofersen for SOD1 ALS
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The peptide functions as a precision senolytic agent by competing with endogenous FOXO4 for p53 binding, releasing the tumor suppressor protein to trigger apoptosis specifically in cells that have accumulated the senescence-associated secretory phenotype (SASP) markers
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