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In summary, the study demonstrates that FOXO4-DRI effectively eliminates senescent Leydig cells, improves the testicular microenvironment, and alleviates age-related testosterone secretion insufficiency, highlighting its therapeutic potential for male late-onset hypogonadism [1]
Up-regulation of EGR-1 and cyclin D1 A bit more technical: EGR-1 (Early Growth Response 1) and cyclin D1 are transcription factors, proteins that, in the cells nucleus, determine which genes are switched on
So that will be useful I think in the literature
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