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Worth noticing: you are still climbing the ladder for the first 16 of those weeks, so most of this happens below the 2.4 mg target dose
The regulatory path differs for injectable vs
Weight loss exceeding 10% is needed for improvement in cardiometabolic outcomes [43], which is the main motivation older adults cite for losing weight [73]
For hepatic impairment specifically, the evidence hierarchy places the current knowledge base at Level 5 (expert opinion and mechanistic reasoning) on the Oxford Centre for Evidence-Based Medicine scale [11]
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