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To date, no studies have demonstrated superiority of SGLT2 inhibitors, GLP1-RAs, or glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonists (GIP/GLP1- RAs) over metformin as first-line therapy in people newly diagnosed with type 2 diabetes
These are not a validated dose ladder: the amounts shown are community / vendor research-use conventions [12] and an animal-derived patent figure [4] , not clinical doses
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Thyroid tumor risk: Tirzepatide carries a black box warning based on rat studies showing dose-dependent thyroid C-cell tumor development
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