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Dysregulation of metabolic peptides precedes hyperinsulinemia and inflammation following exposure to rotenone in rats
A reason for this behaviour could be that H 2 O 2 does not oxidize GSH directly, but rather through the action of glutathione peroxidase 26
These are animal model findings and in vitro studies
3 Multiple REDEFINE clinical trials are currently underway including: REDEFINE 3, an event-driven cardiovascular outcomes phase 3 trial
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