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Preclinical and observational data suggest that side effects primarily depend on dosage, frequency, and individual metabolic response
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Eur J Pediatr 1995;154:686-7
However, when the analysis was restricted to the subgroup of children with DS-CHD, they showed significantly lower SAM:SAH ratio (the DNA methylation potential) than other CHD cases, suggesting that cases of DS-CHD may be associated with global hypomethylation (Obermann-Borst et al., 2011)
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