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Wheeler, Glucagon-Like Peptide-1 Inhibits Pancreatic ATP-Sensitive Potassium Channels via a Protein Kinase A- and ADP-Dependent Mechanism, Molecular Endocrinology, Volume 16, Issue 9, Pages 21352144 Abbildung Created with BioRender.com
This may be linked to common side effects like nausea, fatigue, or loss of appetite
Thus, the GLP-1 WT albiglutide-mimic has comparable FcRn binding characteristics as Tanzeum, while truncation of L585 from the C-terminal end of albumin decreases binding to the receptor
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