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One study that evaluated the results of oral intake of hyaluronic acid over 12 weeks concluded that the results were visible after eight weeks, while after 12 weeks in the group taking hyaluronic acid there was a visible improvement in skin elasticity compared to a control group

The slight difference between the Adjusted R 2 and Predicted R 2 values suggests that the model is reliable and can be confidently used for designing future experiments

The effect plateaued by week 12, suggesting either receptor saturation or compensatory downregulationa detail with protocol implications for researchers designing extended-duration studies