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This suggests that M pro might be particularly efficient at disrupting GSH synthesis, as compared to action at some of the other target sites predicted here, thereby contributing to the clinical findings in COVID-19 ( Finally (Figure 2D), we include a non-canonical hit that would cleave at position 90 of glutaredoxin-1 (GLRX-1)

If only pathway 2 is activated, the existing pathway is triggered without re-initiation

This neuroinflammatory cascade also heavily impacts the autonomic nervous system, contributing to the development of dysautonomia and Postural Orthostatic Tachycardia Syndrome (POTS)