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Retatrutide (Retara), a triple GIP/GLP-1/glucagon agonist, produced the highest mean weight loss in clinical trials (24.2% at 48 weeks)
The Multi-Center Registry for ME/CFS (NCT05778006) develops a large-scale registry to standardize the collection of epidemiological data, facilitate phenotypic stratification, and monitor longitudinal outcomes
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The dedicated cardiovascular trial did not find excess major events and reported lower all-cause mortality, but resting heart rate remains a titration marker rather than a one-time measurement. How to Titrate, and the Cost of Going Too Fast The final dose shapes the endpoint, but escalation speed is the largest modifiable driver of side effects
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