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these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

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When to Increase Fluids or Seek Medical Care Increase fluids if you notice: Darker urine Lightheadedness Headache Muscle cramps Add an electrolyte-containing drink if vomiting or diarrhea occurs

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