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Semaglutide and Cardiovascular Outcomes (SELECT Trial) Cardiovascular benefit of semaglutide in adults with overweight or obesity and established cardiovascular disease PubMed 6

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The metabolic interplay between the vascular and skeletal systems thus emerges as a therapeutic focal point, in which CIT enhances endothelial responsiveness, leucine promotes muscle anabolic processes, and exercise serves to integrate both systems through hemodynamic and molecular stimuli