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RNA sequencing data obtained from the DIO-MASH and CDA-HFD animal studies will be publicly available in the Gene Expression Omnibus ( under their respective data repository accession numbers: GSE294629 and GSE294630

Real-Time PCR To quantify mRNA levels of OA and apoptosis-related gene expression, total RNA was extracted from the cells for in vitro and cartilage for in vivo according to the manufacturers instructions (iNtRON Biotechnology, South Korea)

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Wegovy can delay gastric emptying, particularly during treatment initiation, which could theoretically affect the absorption and transit of other orally administered medications