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doi: 10.1084/jem.20060925 13 FilippiMD
Each additional pathway fills a gap that the others cannot reach
Complement system can be directly activated by hepatocytes through antibody recognition, lack of membrane-bound regulators, and extracellular matrix proteins exposure ( T and C5b T ( Collectively, TF-initiated coagulation activates the IBMIR with interactions between coagulation, complement system, and immune response promote IBMIR process
It is widely available in skincare and is not a controlled substance, though it is regulated as a cosmetic rather than a drug
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