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In TRIUMPH-2 (n=1,152), retatrutide met its primary endpoint with mean weight reductions of 12.7%, 19.1% and 20.8% across the 4 mg, 8 mg and 12 mg doses at week 80, versus 4.0% for placebo
A realistic oral titration schedule might look like: Week 1-4: 50 mg daily (equivalent to ~2.5 mg injected weekly) Week 5-8: 100 mg daily (equivalent to ~5 mg injected weekly) Week 9-12: 150 mg daily (equivalent to ~7.5 mg injected weekly) Each dose increase requires a larger absolute dose increment (50 mg, not 2.5 mg), which means each titration step exposes the patient to a larger pharmacokinetic jump
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