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Depolarization of the axon at the Nodes of Ranvier is caused by the opening of voltage gated sodium channels that allow the influx of positively charged sodium ions
Multiple microbial metabolites could dock with the six enzyme proteins mentioned above, suggesting that there was a potential cross-talk between microbiota and mitochondria
This histopathological hallmark enables the observation of lesion rims by MRI and correlates with high levels of serum neurofilament light chain, therefore with axonal injury, and with disease severity (141, 142)
PMID: 28 DevasundaramS.DeenadayalanA.RajaA
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