Even in small amounts vitamin C can protect indispensable molecules in the body, such as proteins, lipids (fats), carbohydrates, and nucleic acids (DNA and RNA), from damage by free radicals and reactive oxygen species (ROS) that are generated during normal metabolism, by active immune cells, and through exposure to toxins and pollutants (e.g., certain chemotherapy drugs and cigarette smoke)
Modern testing steps in to bridge this gap effectively: - Provocholine, a methacholine challenge test, offers an evidence-based method to confirm or rule out airway hyperresponsiveness
Instead, it exemplifies how endogenous peptides exhibiting multi-receptor activity were historically disadvantaged by a development paradigm that prioritized single-target selectivity over physiological relevance
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