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We need more long-term studies to determine whether rebound weight gain is avoidable, including whether lifestyle interventions can stave off weight gain or if you need to take GLP-1s forever to prevent weight gain

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We conclude that E2 directly controls both - and L cells to increase GLP-1 secretion, in addition to its effects on insulin and glucagon secretion, highlighting the potential beneficial role of the estrogenic pathway and, more particularly, of ER agonists to prevent type 2 diabetes

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