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IGF-1 support More GH means more downstream IGF-1

BPC 157 was studied almost exclusively by the same Croatian team that created it, doing rat study after rat study, while MK-677 was the domain of the Merck Research Laboratories in New Jersey, whose scientists conducted multiple small trials in humans in the 1990s, trying to see if the drug had interesting effects on a variety of surrogate markers

Patients on thyroid hormone replacement should be aware that increased lipolysis can transiently shift free fatty acid levels, which may alter thyroid hormone binding in vitro, though this is unlikely to be clinically significant [4]

A 2025 systematic review identified 36 studies from 1993 to 2024, including 35 preclinical studies and only 1 clinical study