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Report suspected adverse reactions to the Medicines and Healthcare products Regulatory Agency (MHRA) through the Yellow Card Scheme at yellowcard.mhra.gov.uk

Common Clinical Use The most commonly used PDE-4 inhibitor is roflumilast, indicated for: Severe COPD associated with chronic bronchitis Patients with frequent COPD exacerbations It is usually used as add-on therapy to bronchodilators

I've had some low-level nausea and can't eat mustard (no idea why) or orange pekoe tea, but I've been able to eat and drink pretty much everything else

However, when used as prescribed for appropriate durations, it is generally safe and effective