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During TB infection, HDT modulates host cell functions, enhances protective immune responses, and improves the mycobacterial killing activities of host immune cells, working to eradicate or limit TB infection [4, 5]

In phase III trials, these agents have demonstrated an average A1C decrease of about 0.5% when administered as monotherapy

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However, apparent injury of normal organs could be observed in mice that were treated with free DOX (Supplementary Fig