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Research published in Science Translational Medicine (2015) demonstrated that elevated B12 levels can alter the gene expression patterns of these bacteria, specifically downregulating genes involved in B12 synthesis within the bacterial cells

Ipamorelin is not FDA-approved (a research chemical, 503A category 2)

Bloodbrain barrier and BCB are guarding systems of the brain formed mainly by endothelial cells, which separate the central nervous system (CNS) from the general circulatory system of the body, protecting the brain from toxic metabolites and pathogens (Zenaro et al., 2017)

If you want to iron out your wrinkles, then vitamin-C should be your choice