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Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome
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The peptides may have potential roles as adjunctive therapies or alternative treatments for patients who cannot tolerate or do not respond adequately to conventional treatments, but this should be based on careful risk-benefit analysis and appropriate patient selection
2009 Sep;139(9):1744-50
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