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In head-to-head clinical trials and real-world studies, tirzepatide consistently delivers greater weight loss (up to 22.5% vs 15%), superior A1C reduction (-2.3% vs -1.8%), and a higher proportion of patients achieving clinically meaningful weight loss thresholds

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B12 levels increased significantly more for pregnant than non-pregnant women when given an oral dose of 1,000 g (respective increase of 195 vs 117 pmol/l) or 500 g (respective increase of 147 vs 95 pmol/l), but not for 250 g (respective increase of 11 vs