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Additionally, tirzepatide demonstrated significantly greater improvements than semaglutide at 72 weeks in cardiometabolic risk parameters, including systolic and diastolic blood pressure (SBP, DBP), haemoglobin HbA1c, fasting insulin, triglycerides, and high-density lipoprotein (HDL) cholesterol

In animal studies, creatine has been shown to enhance energy production when ADP is limited