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386,387 Autophagy-inducing small molecules and natural compounds Additional autophagy-inducing agents include lithium, which induces autophagy via inhibition of inositol monophosphatase and reduces tau and amyloid- aggregation in AD models, 388 and SMER28, a small-molecule enhancer of rapamycin that promotes autophagy and reduces tau and -synuclein aggregation in AD and PD models
Oral glutathione has poor bioavailability it is largely broken down in the gastrointestinal tract before reaching systemic circulation
The clinical development that reached approval narrowed the receptor profile away from MT-II's non-selective signature
This family includes alpha- linolenic acid, EPA, and DHA
