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Characterization of the inhibitory mechanism of 1-methyl-4-phenylpyridinium and 4-phenylpyridine analogs in inner membrane preparations
Nevertheless, future clinical randomized trial is warranted to determine the effectiveness of currently used therapies
In the liver, OCT1 ( SLC22A1 ), and to a lesser extent OCT3 ( SLC22A3 ), serve as the principal mediators of hepatic metformin uptake, supporting the high intrahepatic accumulation of metformin [32,33]
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