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The Phase 2 trial used 2mg as the starting dose, and it is the lowest dose in the standard published titration: 2mg, then 4mg, then 8mg, then 12mg, each held for 4 weeks
Clinical trials show average weight loss of 24 kg over 48 weeks at the lowest dose, though individual results vary widely based on metabolic factors, adherence, and lifestyle
In the original mouse work it was described as well-tolerated, but that is the limit of the in-vivo safety evidence, and it is mouse-only
30 mg/dL or 1.6 mmol/L above their current trigger
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