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A 2025 meta-analysis (a study that pools data from multiple trials to find patterns) confirmed this ranking, with retatrutide showing a mean difference of -16.34 kg vs tirzepatide's -11.82 kg vs placebo (J Endocrine Soc, 2025)
They act as biological response modifiers, activating or suppressing immunity in response to stimuli
Quality Check was performed according to the established pipeline used by previous epidemiological studies and international metabolomics consortia [31, 43,44,45]
Figure 2 ALC regulated hepatic mRNA and protein levels of cholesterol metabolism-related genes in mice To clarify the mechanism by which ALC affects plasma lipid levels in mice, we analyzed hepatic gene and protein expression related to cholesterol metabolism
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