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In the FIGHT trial on patients hospitalized for HFrEF, Liraglutide did not show benefit on time to death, time to rehospitalization for heart failure, and time-averaged proportional change in N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels from baseline to 180 days [51]

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The safety evaluation demonstrated that semaglutide treatment had a slightly higher incidence rate of total adverse events compared with placebo (RR 108, 95% CI 104 to 112

A responsible practitioner should explain: The expected benefits of a recommendation Possible risks and side effects Reasonable alternatives The quality and limitations of available evidence How progress will be measured When treatment should be changed or stopped When referral to another healthcare professional is appropriate Be cautious of providers who promise cures, discourage needed medical care, recommend extensive testing without a clear purpose, or cannot explain their professional credentials