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Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element: degradation of Nrf2 by the 26 S proteasome
This treatment is typically recommended for adults with obesity or those who have a BMI of 27 or higher with related health conditions such as diabetes, high blood pressure, or high cholesterol, and can be a valuable tool for achieving long-term weight management when combined with a healthy lifestyle
Before prescribing, clinicians should confirm appropriate indicationseither inadequately controlled type 2 diabetes or obesity with BMI 30 kg/m (or 27 kg/m with weight-related comorbidities such as hypertension or dyslipidemia)
M.LeeuwenburghC.et al (2010)
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