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In addition, we show that inhibition of ferroptosis can result in attenuation of A-related lipid peroxidation and an increase in the expression of iron storage proteins in brain cortical organoids differentiated from iPSCs of AD patients compared to their isogenic controls
The decline of NAD + with age results from three converging factors: (1) increased activity of CD38, a NADase whose expression increases with age-related chronic inflammation (inflammaging), (2) reduced biosynthesis via the NAMPT (nicotinamide phosphoribosyltransferase) and NMN pathways, and (3) increased demand for NAD+ by PARP-1 to repair increasing oxidative DNA damage
10.1007/s12072-014-9528-6 88
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