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Hajek T, Calkin C, Blagdon R, Slaney C, Uher R, Alda M
It is noted here that although it is known that TCF7L2 functions as a transcriptional factor of GLP-1 receptor gene in pancreatic -cells 20 , it is not thought that ICAM1 and PAI-1 are the downstream of TCF7L2
These effects include their ability to modulate cellular energy metabolism, hinder tumor growth and cell proliferation, downregulate inflammatory cytokines and chemokines, regulate genes associated with cell cycle and division, induce apoptosis, or influence specific signaling pathways (Verma et al
Science 328 , 321326 (2010)
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